Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity?

Senear-Usher syndrome with parathyroid adenoma.

There has been recent interest in the association between buUous erythema multiforme (Basler, 1973), bullous pemphigoid (Parsons & Savin, 1968), pemphigus vulgaris (Saikia, 1972) and Senear-Usher syndrome (Saikia & MacConnell, 1972) with various neoplasms. A 46-year-old male patient presented with pemphigus erythematosus which was refractory to various forms of therapy including large doses of ...

Pemphigus erythematosus (Senear Usher syndrome)= عاقفلا يمامحلا --رشوأرينيس PEMPHIGUS

Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome

Glutamic acid decarboxylase (GAD) is the enzyme that synthesizes the neurotransmitter gamma-aminobutyric acid (GABA) in neurons and in pancreatic beta cells. It is a major target of autoimmunity in Stiff-Man syndrome (SMS), a rare neurological disease, and in insulin-dependent diabetes mellitus. The two GAD isoforms, GAD-65 and GAD-67, are the products of two different genes. GAD-67 and GAD-65 ...

Human transaldolase and cross-reactive viral epitopes identified by autoantibodies of multiple sclerosis patients.

Multiple sclerosis is mediated by an autoimmune process causing selective destruction of oligodendrocytes. Transaldolase, which is expressed in the brain selectively in oligodendrocytes, is a target of high affinity autoantibodies in serum and cerebrospinal fluid of multiple sclerosis patients. A three-dimensional model of human transaldolase was developed based on the crystal structure of the ...

Demonstration of natural autoantibodies against the neurofilament protein alpha-internexin in sera of patients with endocrine autoimmunity and healthy individuals.

Serum anti-pituitary antibodies (APAs) to cytosolic antigens have been found in association with autoimmune hypophysitis, idiopathic hypopituitarism, and other autoimmune endocrinopathies. Here, an immunoblot method was used to search for serum autoantibody (AAb) reactivities against pituitary antigens, including nuclear and cytoskeletal proteins, in six patients with idiopathic hypopituitarism...